C5-07: Mechanisms of innate drug sensitivity in malignant pleural mesotheliomas
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چکیده
منابع مشابه
Malignant pleural mesotheliomas: an environmental health risk in southeast Turkey.
Accessible online at: www.karger.com/journals/res Natural asbestos deposits pose a health hazard not to be neglected in some European and non-European countries. According to our information, about 113 asbestos deposits are known in Turkey, of which 65% contain chrysotile, 39% tremolite and 1% crocidolite. Whereas industrial exploitation is only of minor importance, domestic and agricultural us...
متن کاملTwo malignant pleural mesotheliomas with unusual histological features.
Morphologically, mesotheliomas may be composed of epithelial and/or sarcomatous elements with various patterns, such as tubular, papillary, tubulopapillary, and diffuse epithelial or mixtures of these. Two cases are descirbed in which, in addition to typical mesothelioma, there was cartilage with foci of calcification and ossificated with the mesothelioma, which suggested that they formed an in...
متن کاملEpidemiology of malignant pleural mesotheliomas in Croatia in the period from 1989 to 1998.
Malignant pleural mesotheliomas are rare tumors. Their occurrence is often associated with the exposure to asbestos. Asbestos is widely used in various industries as well as for many types of products in everyday use. In Croatia in the period from 1989 to 1998, the rate of incidence was 0.4-1.1/100,000. The highest rate of incidence was in the Districts of Istria (2.9) and Split-Dalmatia (2.5)....
متن کاملCytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors.
PD-L1 immunohistochemical staining does not always predict whether a cancer will respond to treatment with PD-1 inhibitors. We sought to characterize immune cell infiltrates and the expression of T-cell inhibitor markers in PD-L1-positive and PD-L1-negative malignant pleural mesothelioma samples. We developed a method for immune cell phenotyping using flow cytometry on solid tumors that have be...
متن کاملThe aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas.
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta superfamily. Recent studies have showed that aberrant methylation of BMP genes is present in several types of human cancer. We examined the expression and methylation status of BMP3b and BMP6 in malignant pleural mesotheliomas (MPMs). The expression status of BMP3b, and BMP6 mRNAs were examined in seven MPM cell li...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2007
ISSN: 1556-0864
DOI: 10.1097/01.jto.0000283222.71391.44